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Cryo Electron Tomography (CryoET)

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Cryogenic electron tomography


Cryogenic electron tomography (cryoET) is an imaging technique used to reconstruct high-resolution (~1–4 nm) three-dimensional volumes of samples, often (but not limited to) biological macromolecules and cells. cryoET is a specialized application of transmission electron cryomicroscopy (CryoTEM) in which samples are imaged as they are tilted, resulting in a series of 2D images that can be combined to produce a 3D reconstruction, similar to a CT scan of the human body. In contrast to other electron tomography techniques, samples are imaged under cryogenic conditions (< −150 °C). For cellular material, the structure is immobilized in non-crystalline, vitreous ice, allowing them to be imaged without dehydration or chemical fixation, which would otherwise disrupt or distort biological structures.

Read more about 'Cryogenic electron tomography' at: Wikipedia

Wikipedia contributors. "Cryogenic electron tomography." Wikipedia, The Free Encyclopedia. Wikipedia, The Free Encyclopedia, Feb. 19, 2024.

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