We use an integrated structural electron microscopy approach to study the biological structures of membrane-associated protein complexes. Our main methods of investigation are single-particle electron cryo-microscopy (cryo-EM) as well electron cryo-tomography (cryo-ET) that we are also developing to advance existing imaging technologies towards high-resolution structural biology.
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With different photon-based technologies we investigate energy conversion and structural changes of molecules during chemical reaction. Precisely, we study the reacting molecules' time-dependent electronic and spatial behaviour. Beside developments in ultrafast optical spectroscopy, we continue to develop so-called "molecular movie methods" in the time-resolved and ultrafast X-ray field which include …
We research the next generation of biomedical imaging techniques.
With noninvasive approaches, we aim to advance both biological research and clinical practice by developing new targeted contrast agents and novel imaging modalities.
