Helmholtz Imaging CONNECT

Go back Home Labs Sachse Lab

Sachse Lab (Sachse Lab)

We use an integrated structural electron microscopy approach to study the biological structures of membrane-associated protein complexes. Our main methods of investigation are single-particle electron cryo-microscopy (cryo-EM) as well electron cryo-tomography (cryo-ET) that we are also developing to advance existing imaging technologies towards high-resolution structural biology.

Carsten Sachse

©Carsten Sachse

Weblinks

sachse.fz-juelich.d…

Sachse Lab in Helmholtz Imaging CONNECT:

Expert

Helmholtz Imaging Support

Helmholtz Imaging offers support for any imaging challenge, independent of the modality. If you do not find the expert here you are looking for, please don't hesitate to contact us!

More than 30 imaging experts are ready to help you.

No application found.

Modality

Cryo focused ion beam (Cryo-FIB)

Focused ion beam, also known as FIB, is a technique used particularly in the semiconductor industry, materials science and increasingly in the biological field for site-specific analysis, deposition, and ablation of materials. A FIB setup …

In Helmholtz Imaging CONNECT
➤Applications: 0 ➤Facilities: 1 ➤Centers: 2 ➤Instruments: 1 ➤Labs: 1 ➤Experts: 1 ➤Solutions: 0

Modality

Negative staining

In microscopy, negative staining is an established method, often used in diagnostic microscopy, for contrasting a thin specimen with an optically opaque fluid. In this technique, the background is stained, leaving the actual specimen untouched, …

In Helmholtz Imaging CONNECT
➤Applications: 0 ➤Facilities: 1 ➤Centers: 2 ➤Instruments: 1 ➤Labs: 1 ➤Experts: 1 ➤Solutions: 0

Facility

Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C)

The Ernst Ruska-Centre (ER-C) for Microscopy and Spectroscopy with Electrons is a national user facility open to universities, research institutions and research laboratories in industry. The ER-C is run conjointly by Forschungszentrum Jülich GmbH and …

In Helmholtz Imaging CONNECT
➤Applications: 0 ➤Centers: 1 ➤Instruments: 16 ➤Labs: 2 ➤Modalities: 35 ➤Experts: 5 ➤Solutions: 0

Center

Deutsches Elektronen-Synchrotron (DESY)

DESY is one of the world’s leading accelerator centres. Researchers use the large-scale facilities at DESY to explore the microcosm in all its variety – from the interactions of tiny elementary particles and the behaviour …

In Helmholtz Imaging CONNECT
➤Applications: 153 ➤Facilities: 4 ➤Instruments: 21 ➤Labs: 85 ➤Modalities: 236 ➤Experts: 33 ➤Solutions: 4

Center

Forschungszentrum Jülich (FZJ)

Forschungszentrum Jülich is a large-scale national research facility in the Helmholtz Association of German Research Centres. By conducting research on the global challenges currently facing society, we contribute to the welfare of mankind and responsible …

In Helmholtz Imaging CONNECT
➤Applications: 52 ➤Facilities: 3 ➤Instruments: 23 ➤Labs: 16 ➤Modalities: 65 ➤Experts: 21 ➤Solutions: 6

Instrument

TFS Aquilos 2 Cryo-FIB (Aquilos)

The Aquilos 2 is a dual beam FIB-SEM platform specifically designed for sectioning of cryo-fixed samples, producing thin lamellae suitable for cryo-electron tomography at an TEM in an automated batch method. Updated with the integrated …

In Helmholtz Imaging CONNECT
➤Applications: 0 ➤Facilities: 1 ➤Centers: 1 ➤Labs: 1 ➤Modalities: 2 ➤Experts: 0 ➤Solutions: 0

Instrument

TFS Talos Arctica G2 (Talos Arctica)

ThermoFisher Talos Arctica at 200 kV for cryo-EM data collection

The Talos Arctica is equipped with a Gatan Bioquantum K3 detector. For negative staining and cryo-EM, we use a ThermoFisher Talos L120C from ThermoFisher Instruments. …

In Helmholtz Imaging CONNECT
➤Applications: 0 ➤Facilities: 1 ➤Centers: 1 ➤Labs: 1 ➤Modalities: 2 ➤Experts: 0 ➤Solutions: 3

Instrument

TFS Talos L120C EM (Talos 120)

The Talos L120C Electron microscope is a robust tool routinely used for initial screening of a biological sample’s purity and homogeneity. The main application at the ER-C is negative staining – a heavy metal embedding …

In Helmholtz Imaging CONNECT
➤Applications: 0 ➤Facilities: 1 ➤Centers: 1 ➤Labs: 1 ➤Modalities: 1 ➤Experts: 0 ➤Solutions: 0

Instrument

TFS Titan Krios G4 (Krios)

The Krios G4 (Thermo-Fisher Scientific) is a 300 kV FEG cryo-electron microscope with X-FEG field emitter and a three-lens condenser system. The detector options are a Gatan BioContinuum energy filter mounted K3 direct electron detection …

In Helmholtz Imaging CONNECT
➤Applications: 0 ➤Facilities: 1 ➤Centers: 1 ➤Labs: 1 ➤Modalities: 4 ➤Experts: 0 ➤Solutions: 3

No solution found.